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NaV1.7 inhibitor-1 manufacturers
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| | NaV1.7 inhibitor-1 Basic information |
| Product Name: | NaV1.7 inhibitor-1 | | Synonyms: | NaV1.7 inhibitor-1;Benzamide, 5-cyclopropyl-N-(cyclopropylsulfonyl)-2-fluoro-4-[(6-methylspiro[2.5]oct-6-yl)methoxy]-;Inhibitor,NaV1.7 inhibitor-1,inhibit,Na channels,NaV1.7 inhibitor1,NaV1.7 inhibitor 1,NaV-1.7 inhibitor-1,Sodium Channel,Na+ channels;NaV1.7 inhibitor-1, 10 mM in DMSO | | CAS: | 1494585-79-3 | | MF: | C23H30FNO4S | | MW: | 435.55 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 1494585-79-3.mol |  |
| | NaV1.7 inhibitor-1 Chemical Properties |
| density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.70±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | NaV1.7 inhibitor-1 Usage And Synthesis |
| Uses | NaV1.7 inhibitor-1 is an efficacious voltage-gated sodium channel (NaV) 1.7 inhibitor with an IC50 of 0.6 nM for hNaV1.7, exhibits 80-fold selectivity versus hNaV1.5[1]. | | IC 50 | h Nav1.7: 0.6 nM (IC50) | | References | [1] Sun S, Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-GatedSodium Channel (NaV) 1.7 with Potent Analgesic Activity. J Med Chem. 2019 Jan 24;62(2):908-927. DOI:10.1021/acs.jmedchem.8b01621 |
| | NaV1.7 inhibitor-1 Preparation Products And Raw materials |
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