| Company Name: |
Ascent Scientific |
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
- QX 314 chloride
-
- $1.10
-
2026-08-20
- CAS:5369-03-9
- Min. Order: 1g
- Purity: 99.0% Min
- Supply Ability: 100 Tons
- QX-314 chloride
-
- $132.00
-
2026-07-15
- CAS:5369-03-9
- Purity: 99.84%
- Supply Ability: 10g
- QX-314 chloride
-
- $132.00
-
2026-07-15
- CAS:5369-03-9
- Purity: 99.84%
- Supply Ability: 10g
|
| | QX 314 chloride Basic information |
| Product Name: | QX 314 chloride | | Synonyms: | QX 314 CHLORIDE;N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)TRIETHYLAMMONIUM CHLORIDE;2-(2,6-Dimethylphenylamino)-N,N,N-triethyl-2-oxoethanaminium chloride;[2-(2,6-dimethylanilino)-2-keto-ethyl]-triethyl-ammonium chloride;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium chloride;[2-[(2,6-dimethylphenyl)amino]-2-oxo-ethyl]-triethyl-azanium chloride;Lidocaine N-ethyl chloride;N-Ethyllidocaine chloride | | CAS: | 5369-03-9 | | MF: | C16H27ClN2O | | MW: | 298.85 | | EINECS: | | | Product Categories: | Ion Channels | | Mol File: | 5369-03-9.mol |  |
| | QX 314 chloride Chemical Properties |
| Melting point | 209-211 °C | | storage temp. | Room temp | | solubility | insoluble in EtOH; ≥14.95 mg/mL in DMSO with gentle warming; ≥22.3 mg/mL in H2O | | form | solid | | color | White | | Water Solubility | Soluble in water (100mM) | | InChI | InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H | | InChIKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N | | SMILES | C1(=C(C)C=CC=C1C)NC(=O)C[N+](CC)(CC)CC.[Cl-] |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | QX 314 chloride Usage And Synthesis |
| Uses | QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model. | | Uses | QX 314 Chloride has been shown to have antitussive properties in mammalian animal models. | | Biological Activity | Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels. | | Biochem/physiol Actions | Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker. | | storage | Room temperature |
| | QX 314 chloride Preparation Products And Raw materials |
|