2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester

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2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester Basic information
Product Name:2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester
Synonyms:2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester;Butanoic acid, 2-(dimethylamino)-4-(2-pyridinyldithio)-, 2,5-dioxo-1-pyrrolidinyl ester;Dimethylamine-SPDB
CAS:1193111-73-7
MF:C15H19N3O4S2
MW:369.46
EINECS:
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Mol File:1193111-73-7.mol
2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester Structure
2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester Chemical Properties
Boiling point 497.8±55.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
pka6.05±0.50(Predicted)
Safety Information
MSDS Information
2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester Usage And Synthesis
UsesDimethylamine-SPDB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
IC 50Disulfide Cleavable Linker; Cleavable Linker
References[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester Preparation Products And Raw materials
Tag:2-(Dimethylamino)-4-(2-pyridinyldithio)butanoic Acid 2,5-Dioxo-1-pyrrolidinyl Ester(1193111-73-7) Related Product Information
2-[2-(2-Azidoethoxy)ethoxy]ethanamine 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1-(2,5-dioxo-1-pyrrolidinyl) ester MC-Val-Cit-PAB Maleimide-DOTA DBCO-NHS Ester Mc-Val-Cit-PABC-PNP