(+/-)-(R,R)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
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Company Name:	Shanghai EFE Biological Technology Co., Ltd.
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Company Name:	Fan De(Beijing) Biotechnology Co., Ltd.
Tel:	15911056312
Email:	liming@bio-fount.com

(+/-)-(R,R)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium manufacturers

(+/-)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium Basic information

Product Name:	(+/-)-(R,R)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium
Synonyms:	(R,R)-(+/-)-4-[2-[(2-(3-CHLOROPHENYL)-2-HYDROXYETHYL)AMINO]PROPYL]PHENOXYACETIC ACID, SODIUM SALT;(±)-(R,R)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid sodium hydrate;BRL 37344 Na Salt;BRL 37344A;BRL 37344 SODIUM;BRL 37344 SODIUM SALT;(R,R)-(+/-)-4-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)phenoxyaceticacid;BRL 37344 hydrate sodium salt
CAS:	127299-93-8
MF:	C19H23ClNNaO4
MW:	387.84
EINECS:
Product Categories:	Adrenoceptor
Mol File:	127299-93-8.mol

(+/-)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium Chemical Properties

storage temp.	Store at RT
solubility	H₂O: 10 mg/mL
form	powder
color	white
Water Solubility	Soluble to 100 mM in water
InChIKey	YTPAKDODIXRQTF-BNTHFPBMSA-M
SMILES	O.[Na+].C[C@H](Cc1ccc(OCC([O-])=O)cc1)NC[C@H](O)c2cccc(Cl)c2

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

(+/-)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium Usage And Synthesis

Uses	BRL 37344 Sodium is a potent and selective b3-AR agonist.
Biological Activity	Potent and selective β 3 adrenoceptor agonist (K i values are 287, 1750 and 1120 nM for β 3 , β 1 and β 2 receptors respectively). Also available as part of the β -Adrenoceptor Agonist Tocriset™ .
Biochem/physiol Actions	BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.
storage	Store at RT
references	[1]. simard pm, atgié c, mauriège p, et al. comparison of the lipolytic effects of norepinephrine and brl 37344 in rat brown and white adipocytes. obes res, 1994, 2(5): 424-431. [2]. kozlovski vi, chlopicki s, gryglewski rj. effects of two beta3-agonists, cgp 12177a and brl 37344, on coronary flow and contractility in isolated guinea pig heart. j cardiovasc pharmacol, 2003, 41(5): 706-713. [3]. reverte m, rivas-cabañero l. effects of the beta 3-adrenoceptor agonist brl 37344 on lipomobilization and plasma glucose levels in conscious fasted rabbits. can j physiol pharmacol, 1996, 74(3): 251-256. [4]. kasahara h, muto s, motokawa y, et al. β3-adrenoceptor-mediated increased circulating transaminase levels in mice treated with its agonist brl 37344. j toxicol sci, 2010, 35(5): 779-784.

(+/-)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium Preparation Products And Raw materials

Tag:(+/-)-(R*,R*)-[4-[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl] amino]propyl]phenoxy]-acetic acid sodium(127299-93-8) Related Product Information

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