(2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate manufacturers
- NAS-181
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- $10568.00
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2026-04-21
- CAS:205242-62-2
- Purity:
- Supply Ability: 10g
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| | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate Basic information |
| | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate Chemical Properties |
| storage temp. | Desiccate at -20°C |
| | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate Usage And Synthesis |
| Uses | NAS-181 is a SR-1B antagonist. | | Biological Activity | Potent, selective antagonist at the rat 5-HT 1B receptor (K i = 47 nM). Increases synthesis and metabolism of 5-HT in the brain following systemic administration and improves passive avoidance retention performance in vivo . | | in vivo | NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1]. | Animal Model: | Rats[1] | | Dosage: | 20 mg/kg | | Administration: | S.c. | | Result: | Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontalcortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (4060%). |
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| | (2R)-2-[[[3-(4-Morpholinylmethyl)-2H-1-benzopyran-8-yl]oxy]methyl]morpholine dimethanesulfonate Preparation Products And Raw materials |
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