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| | Z-Gly-Gly-Phe-chloromethylketone Basic information |
| Product Name: | Z-Gly-Gly-Phe-chloromethylketone | | Synonyms: | N-carbobenzyloxy-Gly-Gly-Phe chloromethyl ketone;Z-GLY-GLY-PHE-CMK;N-cbz-gly-gly-phe chloromethyl ketone;benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate;Glycinamide, N-[(phenylmethoxy)carbonyl]glycyl-N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-;Z-GGF-CMK;Cbz-Gly-Gly-Phe-CMK;Z-Gly-Gly-Phe-chloromethylketone | | CAS: | 35172-59-9 | | MF: | C22H24ClN3O5 | | MW: | 445.9 | | EINECS: | | | Product Categories: | | | Mol File: | 35172-59-9.mol |  |
| | Z-Gly-Gly-Phe-chloromethylketone Chemical Properties |
| Boiling point | 751.7±60.0 °C(Predicted) | | density | 1.281±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 11.03±0.46(Predicted) | | Sequence | {Cbz}-Gly-Gly-Phe-{CMK} |
| | Z-Gly-Gly-Phe-chloromethylketone Usage And Synthesis |
| Uses | Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC50 value of 125 μM[1]. | | References | [1] Moreira W, et, al. Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome. Front Microbiol. 2017 Apr 27;8:746. DOI:10.3389/fmicb.2017.00746 |
| | Z-Gly-Gly-Phe-chloromethylketone Preparation Products And Raw materials |
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