| Company Name: |
Ascent Scientific |
| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
- ODQ
-
- $68.00
-
2026-08-08
- CAS:41443-28-1
- Purity: 98.98%
- Supply Ability: 10g
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| Product Name: | ODQ | | Synonyms: | ODQ;2-OXA-3,5,9B-TRIAZA-CYCLOPENTA[A]NAPHTHALENE-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;ODQ,98%;ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one;1H-[1,2,4]Oxadiazolo[4,3-A]quinoxalin-1-one (9ci);1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ] | | CAS: | 41443-28-1 | | MF: | C9H5N3O2 | | MW: | 187.15 | | EINECS: | | | Product Categories: | Cyclic Nucleotide related;Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Antineoplastic;Signalling | | Mol File: | 41443-28-1.mol |  |
| Melting point | 160-170 °C | | Boiling point | 321.89°C (rough estimate) | | density | 1.3753 (rough estimate) | | refractive index | 1.6500 (estimate) | | RTECS | RO0913150 | | storage temp. | 2-8°C | | solubility | ethanol: 1.2 mg/mL | | form | powder | | pka | 0.94±0.20(Predicted) | | color | pale yellow | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChI | 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H | | InChIKey | LZMHWZHOZLVYDL-UHFFFAOYSA-N | | SMILES | [n]21c(n[o][c]2=O)cnc3c1cccc3 | | CAS DataBase Reference | 41443-28-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29349990 | | Storage Class | 11 - Combustible Solids |
| Description | ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC),IC50= 20 nM).1 ODQ acts via competition with NO for the heme site of sGC where it binds irreversibly.2ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5 | | Chemical Properties | ODQ is off-white to yellow powder | | Uses | ODQ is a selective and potent sGC (soluble guanylyl cyclase) inhibitor. | | Uses | 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase. | | Definition | ChEBI: 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one is a member of the class of oxadiazoloquinoxalines that is 1H-[1,2,4]oxadiazolo[4,3-a]quinoxaline substituted at position 1 by an oxo group. It has a role as an EC 4.6.1.2 (guanylate cyclase) inhibitor. | | Biological Activity | ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase. | | Biochem/physiol Actions | H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction. | | storage | +4°C | | References | [1] J GARTHWAITE. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.[J]. Molecular Pharmacology, 1995, 48 2: 184-188.
[2] A SCHRAMMEL. Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.[J]. Molecular Pharmacology, 1996, 50 1: 1-5.
[3] A G ESTÉVEZ. Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.[J]. Journal of Neuroscience, 1998, 18 10: 3708-3714.
[4] G VANDECASTEELE R F T Eschenhagen. Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes.[J]. Journal of Physiology-London, 1998, 506 ( Pt 3): 653-663. DOI:10.1111/j.1469-7793.1998.653bv.x
[5] M C MARTINS-PINGE O U L G C Araújo. Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats.[J]. Hypertension, 1999, 34 4 Pt 2: 748-751. DOI:10.1161/01.hyp.34.4.748 |
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