N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸
| 中文名称 | N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸 |
|---|---|
| 中文同义词 | N-乙酰基-3-(亚硝基硫代)-缬氨酸;S-亚硝基N-乙酰基-DL-青霉胺;N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸;S-亚硝基-N-乙酰-DL-青霉胺;S-亚硝基-N-乙酰基-DL-青霉胺(SNAP);S-亚硝基-N-乙酰青霉胺P2021044023;库伦法试液隔膜无隔膜式通用-阴阳极液共享;2-乙酰氨基-3-甲基-3-(硫代亚硝基)丁酸 |
| 英文名称 | 2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid |
| 英文同义词 | N-(ACETYLOXY)-3-NITROSOTHIOVALINE;SNAP;(+/-)-S-NITROSO-N-ACETYLPENICILLAMINE;S-NITROSO-N-ACETYL-D,L-PENICILLAMINE;S-Nitroso-N-acetyl-DL-penicillamine,N-Acetyl-3-(nitrosothio)-DL-valine, S-Nitroso-N-acetylpenicillamine, SNAP;(R)-2-acetaMido-3-Methyl-3-(nitrosothio)butanoic acid;SNAP [S-Nitroso-N-acetylpenicillaMine];Anti-SNAP25, C-Terminal antibody produced in rabbit |
| CAS号 | 67776-06-1 |
| 分子式 | C7H12N2O4S |
| 分子量 | 220.25 |
| EINECS号 | |
| 相关类别 | 荧光探针，标记，颗粒和染色;Signalling |
| Mol文件 | 67776-06-1.mol |
| 结构式 |  |
N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸 性质
| 熔点 | 150.5°C |
|---|---|
| 密度 | 1.4261 (rough estimate) |
| 折射率 | 1.5400 (estimate) |
| RTECS号 | YV9383000 |
| 储存条件 | -20°C |
| 溶解度 | H2O:≥2 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.06±0.10(Predicted) |
| 颜色 | 绿色 |
| 水溶解性 | H2O: ≥2mg/mL DMSO: ≥20mg/mL, clear (faint green to very dark green) |
| InChI | 1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12) |
| InChIKey | ZIIQCSMRQKCOCT-UHFFFAOYSA-N |
| SMILES | CC(=O)NC(C(O)=O)C(C)(C)SN=O |
| CAS 数据库 | 67776-06-1(CAS DataBase Reference) |
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种一氧化氮供体，是一种稳定的血小板聚集抑制剂。
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces toxicity of about 80% after 6 hours under normoxic conditions by releasing nitric oxide (NO).
S-Nitroso-N-acetyl-DL-penicillamine has a half-time about 6 hours in in isolated rat ventricular myocytes.
S-Nitroso-N-acetyl-DL-penicillamine (100 µM; 30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes.
Cell Viability Assay
| Cell Line: | Rat liver sinusoidal endothelial cells |
| Concentration: | 2 mM, 5 mM, 10 mM |
| Incubation Time: | 2 hours, 4 hours, 6 hours, 8 hours |
| Result: | Exhibited cytotoxicity against cultivated endothelial cells. |
SNAP (100μM, 300μM) causes small but significant increases of the electrically evoked [
3
H]-acetylcholine release in guinea-pig tracheal.
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-121526 | N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸 S-Nitroso-N-acetyl-DL-penicillamine | 67776-06-1 | 5 mg | 333元 |
| 2025/12/22 | HY-121526 | N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸 S-Nitroso-N-acetyl-DL-penicillamine | 67776-06-1 | 10mg | 500元 |
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