| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
|
| | 5-Chloro-2-methylindole Basic information |
| | 5-Chloro-2-methylindole Chemical Properties |
| Melting point | 112-118 °C | | Boiling point | 140 °C / 0.1mmHg | | density | 1.1705 (rough estimate) | | refractive index | 1.5390 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 16.66±0.30(Predicted) | | form | powder to crystal | | color | White to Gray to Brown | | InChIKey | WUVWAXJXPRYUME-UHFFFAOYSA-N | | CAS DataBase Reference | 1075-35-0(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 24/25-36-26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339990 |
| | 5-Chloro-2-methylindole Usage And Synthesis |
| Chemical Properties | light pink to beige-pale brown crystalline powder | | Uses | 2-Methyl-5-chloroindole has been shown to depress brainstem and telencephalon serotonin for 3 days after 24 hours of being administered intraventricularly.Dyes and metabolites. | | Synthesis Reference(s) | Journal of the American Chemical Society, 96, p. 5495, 1974 DOI: 10.1021/ja00824a028 | | Synthesis | In a 100 mL stainless steel autoclave, 1.09 g (5.1 mmol) of 5-chloro-2-nitrophenylacetone and 72 mg (4 mol%) of cyclopentadienyl ferric dicarbonyl (dimer) were added as a catalyst and 40 g of toluene as a solvent, and the system was protected by nitrogen. After displacing the atmosphere in the reactor three times (10 kgf/cm2 nitrogen each time), carbon monoxide gas was injected to a pressure of 30 kgf/cm2. The reaction mixture was stirred at 120 °C for 5 h. The reaction was completed by cooling to room temperature. Upon completion of the reaction, it was cooled to room temperature and the complete conversion of 5-chloro-2-nitrophenylacetone was confirmed by liquid chromatography analysis. Subsequently, the reaction mixture was post-treated and purified by silica gel column chromatographic separation to afford 0.79 g (94.0% yield) of the target product 5-chloro-2-methylindole. | | References | [1] Patent: US2007/83053, 2007, A1. Location in patent: Page/Page column 7 |
| | 5-Chloro-2-methylindole Preparation Products And Raw materials |
|