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| | 3-Pyrid-4-ylbenzaldehyde Basic information |
| Product Name: | 3-Pyrid-4-ylbenzaldehyde | | Synonyms: | 3-PYRID-4-YLBENZALDEHYDE;3-PYRIDIN-4-YL-BENZALDEHYDE;3-(4-PYRIDINYL)BENZALDEHYDE;3-(4-PYRIDYL)BENZALDEHYDE;AKOS BAR-0608;3-(Pyridin-4-yl)benzaldehyde 97%;3-(3-Fluoropyridin-4-yl)benzaldehyde;3-PYRIDIN-4-YL-BENZALDEHYDE, 95+% | | CAS: | 208190-04-9 | | MF: | C12H9NO | | MW: | 183.21 | | EINECS: | | | Product Categories: | | | Mol File: | 208190-04-9.mol |  |
| | 3-Pyrid-4-ylbenzaldehyde Chemical Properties |
| Melting point | 48 °C | | Boiling point | 341.8±25.0 °C(Predicted) | | density | 1.147±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | 4.72±0.26(Predicted) | | color | Beige | | CAS DataBase Reference | 208190-04-9(CAS DataBase Reference) |
| | 3-Pyrid-4-ylbenzaldehyde Usage And Synthesis |
| Synthesis | Step 1: In a 2L three-necked round-bottomed flask, a nitrogen inert atmosphere was established and maintained. A solvent mixture of 2-propanol/water (800mL/40mL) with pyridine-4-boronic acid (30g, 244mmol, 1.0 eq.), Na2CO3 (77.3g, 729mmol, 3.0 eq.), Pd(OAc)2 (5.46g, 24.3mmol, 0.1 eq.), PPh3 (12.75g, 48.7 mmol, 0.2 equiv) and m-bromobenzaldehyde (45 g, 243 mmol, 1.0 equiv). The reaction mixture was placed in an oil bath at 80 °C and the reaction was stirred for 48 hours. After completion of the reaction, the solid was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:1, v/v) to give 30 g of 3-(pyridin-4-yl)benzaldehyde, the product was in the form of an orange oil. | | References | [1] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2761 - 2766
[2] Patent: WO2013/16807, 2013, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2015/127559, 2015, A1. Location in patent: Page/Page column 31 |
| | 3-Pyrid-4-ylbenzaldehyde Preparation Products And Raw materials |
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