SUBSTANCE P TFA
| 中文名称 | SUBSTANCE P TFA |
|---|---|
| 中文同义词 | SUBSTANCE P TFA;SUBSTANCE P X三氟醋酸盐;化合物 SUBSTANCE P TFA;(S)-2-((S)-1-(L-精氨酰基-L-脯氨酰基-L-赖氨酰基)吡咯烷-2-甲酰氨基)-N1-((S)-5-氨基-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-氨基-4-(甲硫基)-1-氧代丁-2-基)氨基)-4-甲基-1-氧代戊-2-基)氨基)-2-氧代乙基)氨基)-1-氧代-3-苯基丙-2-基)氨基)-1-氧代-3-苯基丙-2-基)氨基)-1,5-二氧代戊-2-基)戊二酰胺 2,2,2-三氟乙酸盐 |
| 英文名称 | Substance P TFA |
| 英文同义词 | Substance P TFA;Neurokinin P TFA;Substance P xTFA;(S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide 2,2,2-trifluoroacetate |
| CAS号 | 148470-19-3 |
| 分子式 | C65H99F3N18O15S |
| 分子量 | 1461.67 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 148470-19-3.mol |
| 结构式 |  |
SUBSTANCE P TFA 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 水：1mg/mL |
| 形态 | 冻干粉 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water: 100 mg/mL |
| 序列 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
Substance P TFA (Neurokinin P TFA) 是一种神经肽，在中枢神经系统中作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R)。
Neurokinin 1 receptor
The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-P0201A | SUBSTANCE P TFA Substance P TFA | 148470-19-3 | 1mg | 500元 |
| 2025/12/22 | HY-P0201A | SUBSTANCE P TFA Substance P TFA | 148470-19-3 | 5mg | 1100元 |