Substance P TFA manufacturers
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| | Substance P TFA Basic information |
| Product Name: | Substance P TFA | | Synonyms: | Substance P TFA;Neurokinin P TFA;Substance P xTFA;(S)-2-((S)-1-(L-Arginyl-L-prolyl-L-lysyl)pyrrolidine-2-carboxamido)-N1-((S)-5-amino-1-(((S)-1-(((S)-1-((2-(((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)pentanediamide 2,2,2-trifluoroacetate | | CAS: | 148470-19-3 | | MF: | C65H99F3N18O15S | | MW: | 1461.67 | | EINECS: | | | Product Categories: | | | Mol File: | 148470-19-3.mol |  |
| | Substance P TFA Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: 1 mg/ml | | form | A lyophilized powder | | color | White to off-white | | Water Solubility | Water: 100 mg/mL | | Sequence | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| | Substance P TFA Usage And Synthesis |
| Uses | Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1]. | | Definition | ChEBI: Substance P is a neuropeptide consisting of 11-amino acids. It preferentially activates neurokinin-1 receptors, exterting excitatory effects on central and peripheral neurons and involved in pain transmission. It has a role as a neurotransmitter, a vasodilator agent and a neurokinin-1 receptor agonist. It is a conjugate base of a substance P(3+). | | IC 50 | NK1; Human Endogenous Metabolite | | References | [1] Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. DOI:10.1091/mbc.6.5.509
[2] Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527. DOI:10.1111/cpr.12527 |
| | Substance P TFA Preparation Products And Raw materials |
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