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CRT0066854 hydrochloride manufacturers
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| | CRT0066854 hydrochloride Basic information |
| | CRT0066854 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | water|48.85|100|DMSO|48.85|100| | | form | Solid | | color | Light yellow to yellow |
| | CRT0066854 hydrochloride Usage And Synthesis |
| Description | Protein kinase C (PKC) inhibitor. Inhibits PKCΙ and PKCζ; (IC50 values are 132 and 639 nM, respectively). Restores polarized morphogenesis in oncogene expressing MDCK cells, decreases colony formation in HeLa cells and inhibits lethal giant larvae 2 (LLGL2) phosphorylation. | | Uses | CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. | | IC 50 | PKCζ: 639 nM (IC50); ROCKII: 620 nM (IC50) | | storage | Store at -20°C | | References | [1] Kjr S, et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J.2013 Apr 15;451(2):329-42. DOI:10.1042/BJ20121871 |
| | CRT0066854 hydrochloride Preparation Products And Raw materials |
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