SK33 manufacturers
- SK33
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- $30.00
-
2026-09-10
- CAS:1928724-23-5
- Purity: 99.66%
- Supply Ability: 10g
- SK33
-
- $30.00
-
2026-07-27
- CAS:1928724-23-5
- Purity: 99.66%
- Supply Ability: 10g
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| Product Name: | SK33 | | Synonyms: | SK33;Androgen Receptor,inhibit,androgen,PC3,cancer,prostate,SK 33,SK-33,Inhibitor,tissue,LNCaP,SK33,analogues,cells;Propanamide, 3-[3,5-bis(trifluoromethyl)phenoxy]-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methyl-;3-(3,5-Bis(trifluoromethyl)phenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;SK33, 10 mM in DMSO | | CAS: | 1928724-23-5 | | MF: | C20H13F9N2O3 | | MW: | 500.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1928724-23-5.mol |  |
| Boiling point | 540.5±50.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (199.88 mM; Need ultrasonic) | | form | Solid | | pka | 12.12±0.29(Predicted) | | color | White to off-white | | InChI | 1S/C20H13F9N2O3/c1-17(33,16(32)31-13-3-2-10(8-30)15(7-13)20(27,28)29)9-34-14-5-11(18(21,22)23)4-12(6-14)19(24,25)26/h2-7,33H,9H2,1H3,(H,31,32) | | InChIKey | VJIVKRQGSGBLFP-UHFFFAOYSA-N | | SMILES | OC(C(NC1=CC(C(F)(F)F)=C(C#N)C=C1)=O)(C)COC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Uses | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1]. | | Biological Activity | SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].
In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].
SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. | | in vivo | SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1]. | Animal Model: | ARE-Luc mice[1] | | Dosage: | 50 mg/kg | | Administration: | Subcutaneously; 24 hours | | Result: | Inhibited AR transcriptional activity. |
| | References | [1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858. |
| | SK33 Preparation Products And Raw materials |
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