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PKF050-638 manufacturers
- PKF050-638
-
- $2500.00
-
2026-07-27
- CAS:528893-52-9
- Purity:
- Supply Ability: 10g
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| | PKF050-638 Basic information |
| Product Name: | PKF050-638 | | Synonyms: | PKF050-638;PKF050 638,PKF-050-638,PKF050638;2-Propenoic acid, 3-[5-(2-amino-5-chlorophenyl)-1H-1,2,4-triazol-1-yl]-, ethyl ester, (2Z)- | | CAS: | 528893-52-9 | | MF: | C13H13ClN4O2 | | MW: | 292.72 | | EINECS: | | | Product Categories: | | | Mol File: | 528893-52-9.mol |  |
| | PKF050-638 Chemical Properties |
| Boiling point | 499.8±55.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | pka | 0.96±0.10(Predicted) |
| | PKF050-638 Usage And Synthesis |
| Description | PKF050-638 is a HIV-1 Rev inhibitor. It acts by interfering with the CRM1-mediated nuclear export and specifically inhibiting Rev-dependent luciferase reporter gene expression. | | Uses | PKF050-638 is a potent and selective inhibitor of HIV-1 Rev (IC50=0.04 μM). PKF050-638 inhibits the CRM1-mediated Rev nuclear export by disrupting CRM1-NES interaction[1]. | | References | [1] Daelemans D, et al. A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export. Proc Natl Acad Sci U S A.2002Oct 29;99(22):14440-5. Epub2002Oct 9. DOI:10.1073/pnas.212285299 |
| | PKF050-638 Preparation Products And Raw materials |
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