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| | SNIPER(ABL)-039 Basic information |
| Product Name: | SNIPER(ABL)-039 | | Synonyms: | SNIPER(ABL)-039;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[2-[2-[2-[3-[[2-[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]acetyl]-2-pyrrolidinyl]-4-thiazolyl]carbonyl]phenoxy]ethoxy]ethoxy]ethoxy]acetyl]-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]- | | CAS: | 2222354-29-0 | | MF: | C54H68ClN11O9S2 | | MW: | 1114.77 | | EINECS: | | | Product Categories: | | | Mol File: | 2222354-29-0.mol |  |
| | SNIPER(ABL)-039 Chemical Properties |
| density | 1.331±0.06 g/cm3(Predicted) | | pka | 10.94±0.70(Predicted) |
| | SNIPER(ABL)-039 Usage And Synthesis |
| Description | DAS-IAP is a novel PROTAC targeting drug-resistant BCR-ABL. | | Uses | SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1]. | | IC 50 | Abl: 0.54 nM (IC50); cIAP1: 10 nM (IC50); cIAP2: 12 nM (IC50); XIAP: 50 nM (IC50); SNIPER; Abl: 10 nM (DC50) | | References | [1] Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. DOI:10.1111/cas.13284 |
| | SNIPER(ABL)-039 Preparation Products And Raw materials |
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