NTFAPI

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NTFAPI Suppliers list
Company Name: Nanchang Tianzhen Biotechnology Co., Ltd  Gold
Tel: 13758194781 13173652190
Email: 522013271@qq.com
Company Name: Tetranov Biopharm  
Tel: 13526569071
Email: sales@leadmedpharm.com
Company Name: YangZhou Ruihong Biotech Co., Ltd.  
Tel: 0514-015380367604 15380367604
Email: sales@ruibobiotech.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 18916372613
Email: yanzihan@shyuanye.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com

NTFAPI manufacturers

  • NOTA-FAPI-04
  • NOTA-FAPI-04 pictures
  • 2025-06-07
  • CAS:2374782-03-1
  • Min. Order: 10mg
  • Purity: >95.00%
  • Supply Ability: 10mg
NTFAPI Basic information
Product Name:NTFAPI
Synonyms:NTFAPI;GFA-1002;NOTA-FAPI-4;(S)-2,2’-[7-[2-[4-[3-[[4-[[2-(2-Cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl]carbamoyl]-6-quinolyl]oxy]propyl]-1-piperazinyl]-2-oxoethyl]-1,4,7-triazonane-1,4-diyl]diacetic Acid;(S)-2,2'-(7-(2-(4-(3-((4-((2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid;NOTA-FAPI-04;NOTA-FAPI-04，NOTA-FAPI-4，NOTA-FAPI4， NTFAPI;NTFAPI, (S)-2,2'-(7-(2-(4-(3-((4-((2-(2-cyano-4,4- difluoropyrrolidin- 1-yl)-2-oxoethyl)carbamoyl)quinolin-6- yl)oxy)propyl)piperazin- 1-yl)-2-oxoethyl)- 1,4,7-triazonane- 1,4- diyl)diacetic acid
CAS:2374782-03-1
MF:C36H47F2N9O8
MW:771.82
EINECS:
Product Categories:
Mol File:2374782-03-1.mol
NTFAPI Structure
NTFAPI Chemical Properties
Boiling point 1061.8±65.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka1.82±0.10(Predicted)
form Solid
color Light yellow to yellow
InChIKeyXQARGGQZFNOLDH-JKXWNSIXNA-N
SMILESC(C1=CC=NC2C=CC(OCCCN3CCN(C(=O)CN4CCN(CCN(CC(=O)O)CC4)CC(=O)O)CC3)=CC1=2)(=O)NCC(N1CC(F)(F)C[C@H]1C#N)=O |&1:51,r|
Safety Information
MSDS Information
NTFAPI Usage And Synthesis
UsesNOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality[1][2][3].
in vivo

18F-AlF-NOTA-FAPI PET/CT showa more metastatic lesions that has more increased activity than 18F-FDG PET/CT[3].

IC 50RDC Bifunctional Chelator
References[1] Wang S, et al. Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4259-4271. DOI:10.1007/s00259-021-05470-5
[2] Guo YH, et al. Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma. Clin Nucl Med. 2021 Nov 1;46(11):929-930. DOI:10.1097/RLU.0000000000003742
[3] Ge L, et al. Preclinical evaluation and pilot clinical study of [18F]AlF-NOTA-FAPI-04 for PET imaging of rheumatoid arthritis. Eur J Nucl Med Mol Imaging. 2022 Oct;49(12):4025-4036. DOI:10.1007/s00259-022-05836-3
NTFAPI Preparation Products And Raw materials
Tag:NTFAPI(2374782-03-1) Related Product Information
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