L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-

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L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Suppliers list
Company Name: Daicel Chiral Technologies (China)CO.,LTD  
Tel: 021-50460086-9 15921403865
Email: han_yajun@dctc.daicel.com
Products Intro: Product Name:VH032-C4-NH2
CAS:2170695-19-7
Purity:95% Package:250MG;1G Remarks:211459
Company Name: Jilin Province Woda Biotechnology Co., Ltd.  
Tel: 13504435624
Email: 1927928688@qq.com
Products Intro: Product Name:VH032-C3-NH2
CAS:2170695-19-7
Purity:98+ Package:1g
Company Name: RD International Technology Co., Limited  
Tel: 18024082417
Email: market@ubiochem.com
Products Intro: Product Name:(S,R,S)-AHPC-C5-NH2
CAS:2170695-19-7
Company Name: Henan Mengtai Pharmaceutical Technology Co., Ltd  
Tel: 17634413542
Email: 1959525201@qq.com
Products Intro: Product Name:(S,R,S)-AHPC-C5-NH2
CAS:2170695-19-7
Purity:98% HPLC
Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
Tel: 51288865780
Email: sales@biosynth.com
Products Intro: Product Name:(S,R,S)-AHPC-C5-NH2
CAS:2170695-19-7
L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Basic information
Product Name:L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
Synonyms:(S,R,S)-AHPC-C5-NH2;VH032-C5-NH2;(2S,4R)-1-[(2S)-2-(6-aminohexanamido)-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
CAS:2170695-19-7
MF:C28H41N5O4S
MW:543.72
EINECS:
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Mol File:2170695-19-7.mol
L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Structure
L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Chemical Properties
Boiling point 829.9±65.0 °C(Predicted)
density 1.213±0.06 g/cm3(Predicted)
pka14.08±0.40(Predicted)
Safety Information
MSDS Information
L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Usage And Synthesis
Uses(S,R,S)-AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader[1].
IC 50VHL
References[1] Lijie Peng, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12;10(5):767-772. DOI:10.1021/acsmedchemlett.9b00025
L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- Preparation Products And Raw materials
Tag:L-Prolinamide, N-(6-amino-1-oxohexyl)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-(2170695-19-7) Related Product Information
Protac linker 5 VH 032-linker 8 (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride E3 ligase Ligand-Linker Conjugates 5 Free Base (S,R,S)-AHPC-C10-NH2 dihydrochloride (S,R,S)-AHPC-C4-NH2