Nw-Propyl-L-arginine hydrochloride manufacturers
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| | Nw-Propyl-L-arginine hydrochloride Basic information |
| Product Name: | Nw-Propyl-L-arginine hydrochloride | | Synonyms: | Nw-Propyl-L-arginine hydrochloride;NωPropylLarginine hydrochloride,Nω Propyl L arginine hydrochloride;(S)-2-Amino-5-(3-propylguanidino)pentanoic acid hydrochloride;Nω-Propyl-L-arginine HCl | | CAS: | 2321366-46-3 | | MF: | C9H21ClN4O2 | | MW: | 252.74 | | EINECS: | | | Product Categories: | | | Mol File: | 2321366-46-3.mol |  |
| | Nw-Propyl-L-arginine hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Oil | | color | Colorless to off-white |
| | Nw-Propyl-L-arginine hydrochloride Usage And Synthesis |
| Uses | Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2]. | | in vivo | Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2]. | Animal Model: | Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2] | | Dosage: | 20 mg/kg | | Administration: | I.p. | | Result: | Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
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| | storage | Desiccate at RT | | References | [1] Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70. DOI:10.1021/jm970550g
[2] Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7. DOI:10.1016/j.ejphar.2004.09.042 |
| | Nw-Propyl-L-arginine hydrochloride Preparation Products And Raw materials |
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