9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- manufacturers
- KL044
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- $149.00
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2026-05-22
- CAS:1801856-93-8
- Purity: 99.05%
- Supply Ability: 10g
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| | 9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Basic information |
| | 9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Chemical Properties |
| Boiling point | 563.3±50.0 °C(Predicted) | | density | 1.30±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (277.92 mM; Need ultrasonic) | | form | Solid | | pka | 11.00±0.70(Predicted) | | color | Off-white to gray |
| | 9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Usage And Synthesis |
| Uses | KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1]. | | Biological Activity | KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1].
KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1]. | | References | [1]. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97. |
| | 9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Preparation Products And Raw materials |
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