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IL-17A inhibitor 1 manufacturers
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| | IL-17A inhibitor 1 Basic information |
| Product Name: | IL-17A inhibitor 1 | | Synonyms: | 1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-;LY-3533028;IL-17A inhibitor 1;inhibit,Inhibitor,Interleukin Related,COPD,Asthma,IL-17A inhibitor 1,IL17A inhibitor 1,IL 17A inhibitor 1;IL-17A inhibitor 1, 10 mM in DMSO;LY3509754 | | CAS: | 2452464-73-0 | | MF: | C24H27F5N8O4 | | MW: | 586.51 | | EINECS: | | | Product Categories: | | | Mol File: | 2452464-73-0.mol |  |
| | IL-17A inhibitor 1 Chemical Properties |
| density | 1+-.0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 11.52±0.46(Predicted) | | form | Solid | | color | Off-white to yellow | | InChIKey | MVWVCLAORBNXSD-UWVAXJGDSA-N | | SMILES | O1N=C(C)C(C(N[C@@H](C2CCC(F)(F)CC2)C2=CN3C(=N2)C=C([C@H](N2C(=O)N[C@H](C(F)(F)F)C2)COC)C=N3)=O)=N1 |
| | IL-17A inhibitor 1 Usage And Synthesis |
| Uses | LY3509754 (IL-17A inhibitor 1) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1]. | | Biological Activity | IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1].
IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%)[1]. | | in vivo | LY3509754 (example 24) possesses high oral bioavailability (F=107%)[1]. | | IC 50 | IL-17 | | References | [1]. COATES DAVID ANDREW, et al. IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS. Patent WO2020146194. |
| | IL-17A inhibitor 1 Preparation Products And Raw materials |
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