Nle4,D-Phe7]-α-MSH (trifluoroacetate salt)

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Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) Basic information
Product Name:Nle4,D-Phe7]-α-MSH (trifluoroacetate salt)
Synonyms:Nle4,D-Phe7]-α-MSH (trifluoroacetate salt)
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MW:0
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Mol File:Mol File
Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) Structure
Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
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MSDS Information
Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) Usage And Synthesis
Description[Nle4,D-Phe7]-a-Melanocyte-stimulating hormone ([Nle4,D-Phe7]-a-MSH) is a peptide agonist of melanocortin receptor I (MC1R).1 It induces cAMP accumulation in mouse L-cells expressing human MC1R (EC50 = 0.5 nM). It also induces tyrosinase activity in mouse melanoma cells.2 In vivo, [Nle4,D-Phe7]-a-MSH (1.8 mg/kg) induces long-term skin darkening in frogs (R. pipiens).3 Formulations containing [Nle4,D-Phe7]-a-MSH have been used in the treatment of erythropoietic protoporphyria and as tanning agents.WARNING This product is not for human or veterinary use.
References[1] HASKELLLUEVANO C. Binding and cAMP Studies of Melanotropin Peptides with the Cloned Human Peripheral Melanocortin Receptor, hMC1R[J]. Biochemical and biophysical research communications, 1994, 204 3: Pages 1137-1142. DOI: 10.1006/bbrc.1994.2581
[2] T K SAWYER. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1980, 77 10: 5754-5758. DOI: 10.1073/pnas.77.10.5754
[3] MAC E. HADLEY. Calcium-Dependent Prolonged Effects on Melanophores of [4-Norleucine, 7-D-Phenylalanine]-α-Melanotropin[J]. Science, 1981, 213 4511. DOI: 10.1126/science.6973820
Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) Preparation Products And Raw materials
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