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| | parsalmide Basic information |
| Product Name: | parsalmide | | Synonyms: | 5-Amino-N-butyl-2-(2-propynyloxy)benzamide;MY-41-6;Parsal;5-Amino-N-butyl-2-(2-propyn-1-yloxy)benzamide;parsalmide;Benzamide, 5-amino-N-butyl-2-(2-propyn-1-yloxy)- | | CAS: | 30653-83-9 | | MF: | C14H18N2O2 | | MW: | 246.3 | | EINECS: | 250-274-2 | | Product Categories: | | | Mol File: | 30653-83-9.mol |  |
| | parsalmide Chemical Properties |
| Melting point | 83-85℃ | | Boiling point | 389.31°C (rough estimate) | | density | 1.107 | | refractive index | 1.5500 (estimate) | | pka | pKa (aq soln, 20°) 4.6 ±0.03 |
| | parsalmide Usage And Synthesis |
| Originator | Parsalmide,Shanghai Lansheng Corporation | | Definition | ChEBI: Parsalmide is a member of benzamides. | | Manufacturing Process | 5-Acetylamino-2-acetoxybenzoyl chloride was obtained by reaction of 5acetylamino-2-acetoxy-benzoic acid with thionylchloride.
5-Acetylamino-N-butyl-2-hydroxybenzamide was produced in the result of treatment of 5-acetylamino-2-acetoxybenzoyl chloride with butylamine in the
presence of sodium hydroxide
5-Acetamino-N-(n-butyl)-2-propargyloxybenzamide was obtained by reaction of 5-acetylamino-N-butyl-2-hydroxybenzamide with propargylbromide in the presence of sodium, isopropyl alcohol and sulfuric acid.
28.8 g (0.1 mole) 5-acetamino-N-(n-butyl)-2-propargyloxybenzamide in 320 ml of 4 N sulfuric acid was heated, under stirring, at 90°-95°C for 2 h. The clear solution was cooled and its pH adjusted to 1 with 1 N NaOH; after filtering, further alkali was subsequently added until a pH of 10 was obtained. At this point the product was separated by filtration and recrystallized from ethanol at 60°C to give 16.6 g (a yield of 68%) of chromatographically pure 5-amino-N-(n-hutyl)-2-propargyloxybenzamide; melting point 85°-87°C. | | Therapeutic Function | Muscle relaxant, Antiinflammatory, Analgesic |
| | parsalmide Preparation Products And Raw materials |
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