2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-

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2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Suppliers list
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2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Basic information
Product Name:2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-
Synonyms:2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-;5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-methyl-8-(piperidin-4-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrimidine-2,4-diamine
CAS:1893419-37-8
MF:C27H32ClN5O4S
MW:558.09
EINECS:
Product Categories:
Mol File:1893419-37-8.mol
2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Structure
2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Chemical Properties
Boiling point 717.6±70.0 °C(Predicted)
density 1.336±0.06 g/cm3(Predicted)
pka10.11±0.10(Predicted)
Safety Information
MSDS Information
2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Usage And Synthesis
UsesDirozalkib (Compound 4) is the inhibitor for ALK with an IC50 of 0.9 nM. Dirozalkib exhibits anti-proliferative activity in cancer cells NCI-H3122, Karpas-299 and NCI-H2228 with IC50s of 130.4, 0.71 and 15.11 nM, respectively. Dirozalkib exhibits good pharmacokinetics characteristics with an bioavailbility of 30%~50%[1].
References[1] Wu Y, et al., Polycyclic anaplastic lymphoma kinase inhibitor. WO2016050171
2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- Preparation Products And Raw materials
Tag:2,4-Pyrimidinediamine, 5-chloro-N2-[2,3-dihydro-7-methyl-8-(4-piperidinyl)-1,4-benzodioxin-5-yl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-(1893419-37-8) Related Product Information
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