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| | 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- Basic information |
| | 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- Chemical Properties |
| Boiling point | 447.7±45.0 °C(Predicted) | | density | 1.56±0.1 g/cm3(Predicted) | | form | Solid | | pka | 3.71±0.10(Predicted) | | color | White to off-white |
| | 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- Usage And Synthesis |
| Uses | ALKBH5-IN-3 (Compound 20m) is a potent and selective ALKBH5 inhibitor, with an IC50 of 21 nM. ALKBH5-IN-3 could efficiently stabilize ALKBH5 in HepG2 cells and increase m6A level in intact cells[1]. | | References | [1] Fang Z, et, al. Discovery of a potent, selective and cell active inhibitor of m6A demethylase ALKBH5. Eur J Med Chem. 2022 Aug 5:238:114446. DOI:10.1016/j.ejmech.2022.114446 |
| | 1H-Pyrazole-3-carboxylic acid, 5-hydroxy-1-[3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials |
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