1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)-

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1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- Basic information
Product Name:1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)-
Synonyms:1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)-;976;L 779976;L779976;L-779976
CAS:214770-19-1
MF:C33H43N7O3
MW:585.75
EINECS:
Product Categories:
Mol File:214770-19-1.mol
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- Structure
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- Chemical Properties
density 1.254±0.06 g/cm3(Predicted)
pka12.02±0.30(Predicted)
Safety Information
MSDS Information
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- Usage And Synthesis
UsesL-779976 is a compound with bradykinin agonist activity. Injection into the amygdala and septum of the rat brain can produce anxiolytic effects. Its bradykinin agonist activity has been verified by relevant experiments.
DefinitionChEBI: L-779976 is a member of the class of indoles that is (betaS)-beta-methyl-D-tryptophan in which the primary amino group undergoes formal condensation with the carboxy group of 4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1-carboxylic acid and the carboxy group undegoes formal condensation with the amino group of (1R,3S)-cyclohexane-1,3-diyldimethanamine. It is a selective nonpeptidic agonist of the somatostatin subtype-2 (SST2) receptor with Ki of 0.05 nM. It has a role as a somatostatin receptor agonist and a neuroprotective agent. It is a secondary carboxamide, a primary amino compound, a member of indoles, a member of benzimidazoles and a piperidinecarboxamide.
References[1] The anxiolytic effects of somatostatin following intra-septal and intra-amygdalar microinfusions are reversed by the selective sst2 antagonist PRL2903 DOI:10.1016/j.pbb.2011.12.012
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- Preparation Products And Raw materials
Tag:1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)-(214770-19-1) Related Product Information
1H-Indole-3-propanamide, N-[[(1R,3S)-3-(aminomethyl)cyclohexyl]methyl]-α-[[[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]carbonyl]amino]-β-methyl-, (αR,βS)- N-[4-(2-Oxo-2,3-Dihydro-1h-Benzimidazol-1- Yl)Piperidin-1-Ylcarbonyl]-[3(S)-Methyl]-D- Tryptophyl-L-Lysine Tert-Butyl Ester 2H-Pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione, 10b-[3-[[(2S,5R)-3,6-dioxo-5-(phenylmethyl)-2-piperazinyl]methyl]-1H-indol-7-yl]-6,10b,11,11a-tetrahydro-3-(phenylmethyl)-, (3R,5aR,10bR,11aS)- Lanreotide acetate Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) DOTA-NOC, DOTA-[Nal3]-octreotide