apovincamine

apovincamine Suppliers list

Company Name:	Sinopharm Chemical Reagent Co,Ltd.
Tel:	86-21-63210123
Email:	sj_scrc@sinopharm.com

Company Name:	S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel:	0755-83725681-603
Email:

Company Name:	Quality Control Solutions Ltd.
Tel:	0755-66853366 13670046396
Email:	orders@qcsrm.com

apovincamine manufacturers

apovincamine Basic information

Product Name:	apovincamine
Synonyms:	Methyl (3alpha,16alpha)-eburnamenine-14-carboxylate;apovincamine;Methyl (13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate;methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate;(3α,16α)-Eburnamenine-14-carboxylic acid methyl ester;Apo-14,15-dehydrovincamine;Apovincaminic acid methyl;(+)-trans-Cavinton
CAS:	4880-92-6
MF:	C21H24N2O2
MW:	336.43
EINECS:	225-491-0
Product Categories:
Mol File:	4880-92-6.mol

apovincamine Chemical Properties

Melting point	160-162℃
Boiling point	405.7±45.0 °C(Predicted)
density	1.30±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	7.82±0.60(Predicted)
color	Off-White to Pale Grey

Safety Information

HS Code

2939800000

MSDS Information

apovincamine Usage And Synthesis

Originator	Apovincamine,GC Promochem
Uses	cis-Apovincamine (Vinpocetine USP Related Compound B), is a vinca alkaloid and a chemical precursor of Vinpocetine (V332500), a derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).
Definition	ChEBI: Apovincamine is an alkaloid.
Manufacturing Process	Apovincamine is semisynthethetic derivative of (+)-vincamine. Vincamine is alkaloid of Vinca minor. Alcoloid of Tabernaemontana rigida (Apocynaceae) also is used as raw material for preparing of apovincamine. (+)- Vincamine was transformed into oxime ester by reaction with NaNO2 in acetic acid at 0°C -(+/-)-methyl-3-((12bR)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3- a]quinolizin-1-yl)-2-(hydroxyimino)propanoate, which was resolved on the isomers with dibenzoyl D-tartratic acid. (-)-Methyl 3-((12bR)-1-ethyl- 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)-2- (hydroxyimino)propanoate was re-crystallized from methanol to afford (-)- methyloxime ester, MP: 195°C. 2 g of above oxime methyl ester was heated in mixture of methanol (37.5 ml) and conc. H2SO4 (13.5 ml) on water bath for 1 hour. The solution was poured into ice-water (80 ml), basified with conc. NH4OH to pH 9, and extracted with CH2Cl2 (3x20 ml). The combined extracts were dried (MgSO4), filtered, evaporated in vacuum and the residue was re-crystallized from MeOH (5 ml) to yield 1.32 g (72.5%) of (+)-apovincamine, MP: 160°-162°C.
Therapeutic Function	Vasodilator

apovincamine Preparation Products And Raw materials

Raw materials

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