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| | 4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Basic information |
| | 4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | pka | 5.95±0.60(Predicted) | | form | Solid | | color | White to off-white |
| | 4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Usage And Synthesis |
| Uses | 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is an inhibitor for bone morphogenetic protein 2 (BMP2) with an IC50 of 2.2 μM. 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles is inhibitor for mitogen-activated protein kinase 1 (MEK1). 3-Hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles exhibits anti-inflammatory and neuroprotective activity in EAE mouse model[1][2]. | | References | [1] Arnon KARNI, Small organic molecules for use in the treatment of neuroinflammatory disorders. WO2018198123.
[2] Varaprasad CV, et al., Discovery of 3-hydroxy-4-carboxyalkylamidino-5-arylamino-isothiazoles as potent MEK1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3975-80. DOI:10.1016/j.bmcl.2006.05.019 |
| | 4-Isothiazolecarbonitrile, 2,3-dihydro-3-oxo-5-[[2-(trifluoromethyl)phenyl]amino]- Preparation Products And Raw materials |
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