Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)-

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Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Products Intro: Product Name:RMC-0331
CAS:2488788-52-7
Package:10mg/;100mg/;1g/;10g/
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
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Products Intro: Product Name:RMC-0331
CAS:2488788-52-7
Purity:98% HPLC Package:5mg，10mg，50mg，100mg，1g，5g
Company Name: Shanghai SuperLan Chemcial Technique Centre  
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Products Intro: Product Name:RMC-0331
CAS:2488788-52-7
Purity:95 Package:1G,5G,10G,50G,100G,1KG
Company Name: Guangzhou Younan Technology Co., Ltd  
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Products Intro: Product Name:RMC-0331
CAS:2488788-52-7
Purity:0.98 Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
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Products Intro: Product Name:1mg;1g;10g;100g;1Kg;
CAS:2488788-52-7
Purity:99.5+HPLC Package:100g/RMB 1000
Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Basic information
Product Name:Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)-
Synonyms:Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)-;RMC-0331;RMC 0331,RMC0331;4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydropyrrolo[3,4-d]pyrimidin-6-yl]-(4-methoxytetrahydropyran-4-yl)methanone;N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-2-chloro-6-(4-methoxyoxane-4-carbonyl)-5H,6H,7H-pyrrolo[3,4-d]pyrimidin-4-amine;RMC-0331, 10 mM in DMSO
CAS:2488788-52-7
MF:C22H25ClF3N5O3
MW:499.91
EINECS:
Product Categories:
Mol File:2488788-52-7.mol
Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Structure
Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Chemical Properties
Boiling point 679.8±55.0 °C(Predicted)
density 1.44±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (250.05 mM; Need ultrasonic)
form Solid
pka3.19±0.11(Predicted)
color White to yellow
Safety Information
MSDS Information
Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Usage And Synthesis
UsesRMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].
Biological ActivityRMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1]. RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1]. RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].
in vivo

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].

References[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.
Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)- Preparation Products And Raw materials
Tag:Methanone, [4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl](tetrahydro-4-methoxy-2H-pyran-4-yl)-(2488788-52-7) Related Product Information