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| | 5-Hydroxy-1-methylpyrazole Basic information |
| | 5-Hydroxy-1-methylpyrazole Chemical Properties |
| Melting point | 110-114 °C | | Boiling point | 217.7±13.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in DMSO, Methanol | | pka | 9.07±0.23(Predicted) | | form | powder to crystal | | color | White to Orange to Green | | InChI | InChI=1S/C4H6N2O/c1-6-4(7)2-3-5-6/h2-3,7H,1H3 | | InChIKey | CMXOTACIOGGSNH-UHFFFAOYSA-N | | SMILES | N1(C)C(O)=CC=N1 |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 2933199090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 5-Hydroxy-1-methylpyrazole Usage And Synthesis |
| Uses | 5-Hydroxy-1-methylpyrazole is a pyrazole derivative used as an intermediate in the preparation of herbicides. | | Synthesis | The general procedure for the synthesis of 1-methyl-5-hydroxypyrazole-4-carboxylic acid from ethyl 1-methyl-5-hydroxypyrazole-4-carboxylate is as follows: 22 g of sodium hydroxide was dissolved in 300 mL of water, 42.5 g of intermediate (ethyl 1-methyl-5-hydroxypyrazole-4-carboxylate) was added, and the reaction was stirred for 3 hr at 40 °C, then cooled to room temperature. 55 mL of concentrated hydrochloric acid was added dropwise, followed by heating and refluxing for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, 200 mL of anhydrous ethanol was added to the residue, and the precipitate was collected by filtration after thorough stirring. The filtrate was concentrated under reduced pressure to give 24 g of white solid product (1-methyl-5-hydroxypyrazole) in 98.0% yield and 96.50% HPLC purity. | | References | [1] Patent: CN105218449, 2016, A. Location in patent: Paragraph 0063; 006=5 |
| | 5-Hydroxy-1-methylpyrazole Preparation Products And Raw materials |
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