4-Benzyl-2-morpholinecarboxylic acid hydrochloride manufacturers
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| | 4-Benzyl-2-morpholinecarboxylic acid hydrochloride Basic information |
| | 4-Benzyl-2-morpholinecarboxylic acid hydrochloride Chemical Properties |
| Melting point | 244 °C | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | color | Brown |
| | 4-Benzyl-2-morpholinecarboxylic acid hydrochloride Usage And Synthesis |
| Synthesis | 4-Benzylmorpholine-2-carbonitrile (64.1 g, 316.9 mmol) was used as the raw material, which was dissolved in 6 N aqueous hydrochloric acid (600 mL) and the reaction was heated to reflux for 2.5 hours. After the reaction was completed, the reaction solution was cooled to -10 °C. The precipitated solid product was collected by filtration and washed with acetone (300 mL) pre-cooled to -10 °C. The resulting solid was dried in an oven at 60 °C to afford 4-benzyl-2-morpholine carboxylic acid hydrochloride (78.7 g, 305.4 mmol, 96% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 2.18 (broad peak, -COOH), 7.67-7.65 (multiple peaks, 2H), 7.53-7.40 (multiple peaks, 3H), 4.61 (double peak, J = 10.8 Hz, 1H), 4.39 (multiple peaks, 2H), 4.05-4.94 (multiple peaks, 2H) , 3.43 (double peak, J = 12.0 Hz, 1H), 3.20-3.07 (multiple peaks, 3H). | | References | [1] Patent: WO2012/128582, 2012, A2. Location in patent: Page/Page column 28
[2] Patent: WO2005/47272, 2005, A1. Location in patent: Page/Page column 48-49
[3] Organic Process Research and Development, 2009, vol. 13, # 2, p. 209 - 224
[4] Patent: WO2010/59658, 2010, A1. Location in patent: Page/Page column 225 |
| | 4-Benzyl-2-morpholinecarboxylic acid hydrochloride Preparation Products And Raw materials |
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