Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI)

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Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) manufacturers
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) Basic information
Product Name:Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI)
Synonyms:(S)-tert-butyl pyrrolidin-3-ylmethylcarbamate;(S)-3-(Boc-aminomethyl)py...;(S)-(3-Pyrrolidinylmethyl)-carbamic acid 1,1-dimethylethyl ester;tert-butyl ((S)-pyrrolidin-3-yl)MethylcarbaMate;Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI);tert-butyl N-[(3S)-pyrrolidin-3-ylmethyl]carbamate;Carbamic acid, N-[(3S)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester;Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl es...
CAS:173340-26-6
MF:C10H20N2O2
MW:200.28
EINECS:
Product Categories:N-BOC
Mol File:173340-26-6.mol
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) Structure
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) Chemical Properties
Boiling point 303.9±15.0 °C(Predicted)
density 0.997
storage temp. 2-8°C(protect from light)
pka12.71±0.46(Predicted)
AppearanceColorless to light yellow Liquid
Safety Information
HS Code 2933998090
MSDS Information
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) Usage And Synthesis
Synthesis
Carbamic acid, [[(3R)-1-[(1S)-1-phenylethyl]-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester (9CI)

173340-24-4

Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI)

173340-26-6

General procedure for the synthesis of (S)-3-N-Boc-aminomethylpyrrolidine from (3R)-1-[(1S)-1-phenylethyl]-3-pyrrolidinylmethyl]carbamic acid,1,1-dimethylethyl ester (9CI): tert-butyl [1-(1-phenylethyl)-pyrrolidin-3-ylmethyl]-carbamate (3.50 g, 11.5 mmol) was dissolved in methanol in methanol, 20% Pd/C catalyst was added and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi.After 24 h, the reaction mixture was filtered and concentrated to afford 1.75 g (S)-3-N-Boc-aminomethylpyrrolidine (yield: 76%). Mass spectrometry analysis (APCI+): m/z 201 ([M+H]+).

References[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 88; 89; 124
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 116; 117; 152
Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) Preparation Products And Raw materials
Raw materialsCarbamic acid, [[(3R)-1-[(1S)-1-phenylethyl]-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester (9CI)-->Methanol-->Hydrogen
Tag:Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI)(173340-26-6) Related Product Information
tert-Butyl ([(3S,4R)-4-phenylpyrrolidin-3-yl]methyl)carbamate tert-Butyl 2,6-diazabicyclo[2.2.1]heptane-2-carboxylate cis-5-Benzyl-2-Boc-hexahydropyrrolo[3,4-c]pyrrole Tert-butyl 2,6-diazaspiro[3.4]octane-2-carboxylate (R)-1-BENZYL-3-N-BOC-AMINOMETHYL PYRROLIDINE (cis)-5-Boc-Hexahydro-pyrrolo[3,4-b]pyrrole R-1-CBZ-3-(BOC-AMINOMETHYL)-PYRROLIDINE Carbamic acid, (3-pyrrolidinylmethyl)-, 1,1-dimethylethyl ester, (S)- (9CI) cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole