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3-([3,5-Bis(trifluoromethyl)phenyl]methoxy)-2-phenyl-piperidine hydrochloride manufacturers
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| | 3-([3,5-Bis(trifluoromethyl)phenyl]methoxy)-2-phenyl-piperidine hydrochloride Basic information |
| | 3-([3,5-Bis(trifluoromethyl)phenyl]methoxy)-2-phenyl-piperidine hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10 mg/mL | | form | solid | | color | white | | Water Solubility | Soluble to 50 mM in water with gentle warming |
| | 3-([3,5-Bis(trifluoromethyl)phenyl]methoxy)-2-phenyl-piperidine hydrochloride Usage And Synthesis |
| Uses | L-733,060 Hydrochloride is an NK-1 inhibitor which is used in the treatment of depression and nausea, associated with cancer chemotherapy. | | in vivo | L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats[1].
L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of <3000 μg/kg in conscious or anaesthetised rats[1]. | Animal Model: | Male Sprague-Dawley rats (200 g) with electrical stimulation of the trigeminal ganglion[1] | | Dosage: | 10, 100, 1000 mg/kg | | Administration: | I.v. injection | | Result: | Produced a significant dose-related inhibition of plasma extravasation with an ID50 of 212±19 μg/kg. |
| | IC 50 | NK1 | | storage | Store at RT |
| | 3-([3,5-Bis(trifluoromethyl)phenyl]methoxy)-2-phenyl-piperidine hydrochloride Preparation Products And Raw materials |
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