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LGM Pharma |
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1-(800)-881-8210 |
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inquiries@lgmpharma.com |
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| | Intoplicine Basic information |
| Product Name: | Intoplicine | | Synonyms: | Intoplicine;11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole;7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl- | | CAS: | 125974-72-3 | | MF: | C21H24N4O | | MW: | 348.44 | | EINECS: | | | Product Categories: | | | Mol File: | 125974-72-3.mol |  |
| | Intoplicine Chemical Properties |
| Melting point | 216-218 °C | | Boiling point | 635.5±55.0 °C(Predicted) | | density | 1.286±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 8.26±0.30(Predicted) | | color | White to off-white |
| | Intoplicine Usage And Synthesis |
| Uses | Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2]. | | Definition | ChEBI: Intoplicine is a pyridoindole. | | in vivo | At the highest non-toxic dose (HNTD) (6 mg/kg/injection, total dose, 36 mg/kg), Intoplicine shows highly active with a T/C of 0% and a corresponding total log cell kill of 3[3]. | | IC 50 | Topoisomerase I; Topoisomerase II | | References | [1] Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86(1):30-3. DOI:10.1093/jnci/86.1.30
[2] Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53(20):4784-90. PMID:8402662
[3] Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11(4):263-277. DOI:10.1007/BF00874425 |
| | Intoplicine Preparation Products And Raw materials |
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