占托西林
| 中文名称 | 占托西林 |
|---|---|
| 中文同义词 | 占托西林;青黴黃素X;黄青霉素;化合物 T17261 |
| 英文名称 | Xantocillin |
| 英文同义词 | XANTHOCILLINX;XANTHOCILINX;Xantocillin;4,4'-(2,3-Diisocyano-1,3-butadiene-1,4-diyl)bisphenol;1,4-Di-p-oxyphenyl-2,3-di-isonitrilo-1,3-butadien;Brevicid;Brevicide;Brevicide-x |
| CAS号 | 580-74-5 |
| 分子式 | C18H12N2O2 |
| 分子量 | 288.3 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 580-74-5.mol |
| 结构式 |  |
占托西林 性质
| 沸点 | 430.53°C (rough estimate) |
|---|---|
| 密度 | 1.2396 (rough estimate) |
| 折射率 | 1.5800 (estimate) |
| 酸度系数(pKa) | 9.013±0.26(predicted) |
Xanthocillin 是从青霉中提取的一种海洋药剂，通过抑制 MEK/ERK 途径诱导自噬。
Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC
50
of 22.88 ± 4.76 µM.
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1.
Cell Proliferation Assay
| Cell Line: | HepG2 cells |
| Concentration: | 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM |
| Incubation Time: | 48 hours |
| Result: | A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC 50 of 22.88 ± 4.76 µM. |
Western Blot Analysis
| Cell Line: | HepG2 cells |
| Concentration: | 24.3 µM |
| Incubation Time: | 12 hours, 24 hours, 48 hours |
| Result: | Increased the expression of the autophagy-related genes, LC3, and Beclin 1. |