| Company Name: |
InvivoChem |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
|
| | Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester Basic information |
| | Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester Chemical Properties |
| Boiling point | 548.3±50.0 °C(Predicted) | | density | 1.514±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 125 mg/mL (288.80 mM; Need ultrasonic) | | pka | 11.68±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester Usage And Synthesis |
| Uses | P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 μM and 1.67 μM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1]. | | References | [1] Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789. DOI:10.1016/j.ejmech.2019.111789 |
| | Benzenesulfonic acid, 4-[(2-chlorobenzoyl)amino]-, 3-nitrophenyl ester Preparation Products And Raw materials |
|