|
|
| | NSC54180 Basic information |
| Product Name: | NSC54180 | | Synonyms: | NSC54180;5-BroMo-2-hydroxy-4-Methyl-benzoic acid;Benzoic acid, 5-bromo-2-hydroxy-4-methyl- | | CAS: | 6623-35-4 | | MF: | C8H7BrO3 | | MW: | 231.04 | | EINECS: | | | Product Categories: | | | Mol File: | 6623-35-4.mol |  |
| | NSC54180 Chemical Properties |
| Melting point | 205-208 °C | | Boiling point | 359.2±42.0 °C(Predicted) | | density | 1.739±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 2.68±0.10(Predicted) | | Appearance | White to off-white Solid |
| | NSC54180 Usage And Synthesis |
| Synthesis | A) Synthesis of 5-bromo-2-hydroxy-4-methylbenzoic acid: 2-hydroxy-4-methylbenzoic acid (5.00 g) was dissolved in acetic acid (70.0 mL) and bromine (1.68 mL) was added slowly and dropwise. The reaction mixture was stirred at room temperature for 5.5 hours. Upon completion of the reaction, water was added to the mixture and the precipitate was collected by filtration. The precipitate was dried under reduced pressure to give the target compound 5-bromo-2-hydroxy-4-methylbenzoic acid (6.78 g). The result of mass spectrometry analysis: [M-H] 229.0. | | References | [1] Patent: WO2018/24224, 2018, A1. Location in patent: Page/Page column 80; 81
[2] Patent: US2018/127370, 2018, A1. Location in patent: Paragraph 0892
[3] Journal of the Chemical Society, 1914, vol. 105, p. 1891
[4] Journal fuer Praktische Chemie (Leipzig), 1915, vol. <2> 91, p. 388
[5] Patent: EP1391451, 2004, A1. Location in patent: Page 84 |
| | NSC54180 Preparation Products And Raw materials |
|