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| | 4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE Basic information |
| Product Name: | 4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE | | Synonyms: | AKOS B029445;4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE;4-(2-methyl-1h-imidazol-1-yl)aniline;4-(2-METHYL-1H-IMIDAZOL-1-YL)PHENYLAMINE;CHEMBRDG-BB 4010370;ASINEX-REAG BAS 08767582;4-(2-methyl-1H-imidazol-1-yl)aniline(SALTDATA: 0.06N2H4 0.2H2O);4-(2-methyl-1H-imidazol-1-yl)benzenamine | | CAS: | 74852-81-6 | | MF: | C10H11N3 | | MW: | 173.21 | | EINECS: | | | Product Categories: | | | Mol File: | 74852-81-6.mol |  |
| | 4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE Chemical Properties |
| Melting point | 111.5 °C | | Boiling point | 378.5±44.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 7.49±0.10(Predicted) | | form | solid | | color | Brown |
| Hazard Codes | Xi | | Risk Statements | 41 | | Safety Statements | 26-39 | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 2933299090 |
| | 4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE Usage And Synthesis |
| Synthesis | GENERAL STEPS: 2-Methyl-1-(4-nitrophenyl)-1H-imidazole (12.8 g, 63 mmol) was dissolved in methanol (150 mL) and palladium/carbon catalyst (3 g) was added. The reaction mixture was stirred for 8 h at room temperature in a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the feedstock, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated under vacuum to afford 4-(2-methyl-1H-imidazol-1-yl)aniline (10 g, 92% yield). | | References | [1] Patent: WO2009/71888, 2009, A1. Location in patent: Page/Page column 83
[2] Advanced Synthesis and Catalysis, 2016, vol. 358, # 4, p. 597 - 609
[3] Patent: WO2011/75478, 2011, A1. Location in patent: Page/Page column 53
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 5, p. 1221 - 1227
[5] Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 1729 - 1744 |
| | 4-(2-METHYLIMIDAZOL-1-YL)PHENYLAMINE Preparation Products And Raw materials |
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