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Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:Xanthineoxidoreductase-IN-4
CAS:1026587-58-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name:Xanthine oxidoreductase-IN-4
CAS:1026587-58-5
Purity:98.25% Package:1mg;63USD|5mg;143USD|10mg;212USD
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:Xanthine oxidoreductase-IN-4
CAS:1026587-58-5
Purity:98% Package:5mg Remarks:S34021
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
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Products Intro: Product Name:Xanthine oxidoreductase-IN-4
CAS:1026587-58-5
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Products Intro: Product Name:Xanthineoxidoreductase-IN-4
CAS:1026587-58-5
Purity:98% Package:50MG;100MG,1G,5G,100G

Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- manufacturers
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Basic information
Product Name:Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-
Synonyms:Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-;Xanthine oxidoreductase-IN-4;N-(4-Ethoxyphenyl)-4-(1H-tetrazol-5-yl)benzamide
CAS:1026587-58-5
MF:C16H15N5O2
MW:309.32
EINECS:
Product Categories:
Mol File:1026587-58-5.mol
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Structure
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Chemical Properties
density 1.332±0.06 g/cm3(Predicted)
pka3.81±0.10(Predicted)
Safety Information
MSDS Information
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Usage And Synthesis
UsesXanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia[1].
in vivo

Xanthine oxidoreductase-IN-4 (Compound IIIc) (oral; 5 mg/kg) shows a significant hypouricemia effect in a potassium oxazinate/hypoxanthine-induced model of acute hyperuricemia[1].

Animal Model:Mice acute hyperuricemia model[1]
Dosage:5 mg/kg
Administration:Oral
Result:Reduced serum levels of uric acid significantly from 4 h after administration.
References[1] Wen Peng, et al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2022 Nov 28;246:114947. DOI:10.1016/j.ejmech.2022.114947
Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)- Preparation Products And Raw materials
Tag:Benzamide, N-(4-ethoxyphenyl)-4-(2H-tetrazol-5-yl)-(1026587-58-5) Related Product Information
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