FRG 8701

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Company Name: BOC Sciences  
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FRG 8701 manufacturers

  • FRG8701
  • FRG8701 pictures
  • $2500.00
  • 2026-04-21
  • CAS:108498-50-6
  • Purity:
  • Supply Ability: 10g
  • FRG8701
  • FRG8701 pictures
  • $2500.00
  • 2025-08-22
  • CAS:108498-50-6
  • Purity:
  • Supply Ability: 10g
FRG 8701 Basic information
Product Name:FRG 8701
Synonyms:FRG 8701;Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-;FRG8701,FRG-8701;N-(3-(3-(Piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide
CAS:108498-50-6
MF:C22H30N2O4S
MW:418.55
EINECS:
Product Categories:
Mol File:108498-50-6.mol
FRG 8701 Structure
FRG 8701 Chemical Properties
Boiling point 675.2±55.0 °C(Predicted)
density 1.226±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka13.77±0.46(Predicted)
Safety Information
MSDS Information
FRG 8701 Usage And Synthesis
UsesFRG-8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
in vivo

In the pylorus-ligated (4 hr) rats, each drug, given intraduodenally, dose-dependently inhibits the total acid output. FRG8701 at 10 or 30 mg/kg, given orally or intraperitoneally, significantly prevent the formation of the gastric mucosal lesions induced by 0.4 N HCI+50% ethanol (HCIethanol). Other necrotizing agents-induced gastric lesions are also inhibited by treatment of FRG8701. The oral ED50 values against the lesions range from 1.1 to 9.4 mg/kg. FRG8701, given orally, dose-dependently prevents the development of gastric lesions induced by stress and indomethacin. Duodenal ulcer induced by mepirizole is also inhibited with FRG8701. The ED50 values of FRG8701 for each ulcer model range from 1.7 to 6.9 mg/kg[1].

References[1] Shibata M,et al. Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. DOI:10.1254/jjp.54.277
FRG 8701 Preparation Products And Raw materials
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