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| | NPR-C activator 1 Basic information |
| Product Name: | NPR-C activator 1 | | Synonyms: | β-Alanine, N-[4-[[4-(acetylamino)phenyl]amino]-1,3,5-triazin-2-yl]-, 1,1-dimethylethyl ester;N-[4-[[4-(Acetylamino)phenyl]amino]-1,3,5-triazin-2-yl]-β-alanine 1,1-dimethylethyl ester | | CAS: | 2768328-61-4 | | MF: | C18H24N6O3 | | MW: | 372.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2768328-61-4.mol |  |
| | NPR-C activator 1 Chemical Properties |
| density | 1.283±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 14.693±0.70(predicted) | | form | Solid | | color | White to off-white |
| | NPR-C activator 1 Usage And Synthesis |
| Uses | NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ～ 1 μM) with promising in vivo pharmacokinetic properties[1]. | | References | [1] Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65(7):5495-5513. DOI:10.1021/acs.jmedchem.1c01974 |
| | NPR-C activator 1 Preparation Products And Raw materials |
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