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ChemeGen |
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18818260767 |
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| | WIN 66306 Basic information |
| Product Name: | WIN 66306 | | Synonyms: | WIN 66306;cyclo[glycyl-L-tryptophyl-L-prolylglycyl-L-valylglycyl-(βR)-β-hydroxy-3-(3-methyl-2-butenyl)-L-tyrosyl | | CAS: | 151928-32-4 | | MF: | C41H52N8O9 | | MW: | 800.89978 | | EINECS: | | | Product Categories: | | | Mol File: | 151928-32-4.mol |  |
| | WIN 66306 Chemical Properties |
| Sequence | Cyclo(Gly-Trp-Pro-Gly-Val-Gly-{(βR)-β-OH-3-(3-Me-2-Butenyl)-Tyr}) |
| | WIN 66306 Usage And Synthesis |
| Description | WIN 66306 is a cyclic heptapeptide antagonist of neurokinin-1 (NK1) and NK2 receptors originally isolated from A. flavipes. It binds to NK1 and NK2 receptors and inhibits contractions induced by substance P in isolated guinea pig ileum in a concentration-dependent manner. | | Uses | WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors[1][2]. | | References | [1] Barrow CJ, et al. WIN 66306, a new neurokinin antagonist produced by an Aspergillus species: fermentation, isolation and physico-chemical properties. J Antibiot (Tokyo). 1994 Nov;47(11):1182-7. DOI:10.7164/antibiotics.47.1182
[2] Barrow C J, et al. Structure, determination, pharmacological evaluation, and structure-activity studies of a new cyclic peptide substance P antagonist containing the new amino acid 3-prenyl-. beta.-hydroxytyrosine isolated from Aspergillus flavipes[J]. Journal of medicinal chemistry, 1994, 37(3): 356-363. DOI:10.1021/jm00029a007 |
| | WIN 66306 Preparation Products And Raw materials |
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