SDZ MKS 492

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SDZ MKS 492 manufacturers

  • SDZ-MKS 492
  • SDZ-MKS 492 pictures
  • $297.00
  • 2026-05-11
  • CAS:114606-56-3
  • Purity:
  • Supply Ability: 10g
SDZ MKS 492 Basic information
Product Name:SDZ MKS 492
Synonyms:SDZ MKS 492;MKS 492;1H-Purine-2,6-dione, 8-[[(1R)-1-(3,4-dimethoxyphenyl)-2-hydroxyethyl]amino]-3,7-dihydro-7-(2-methoxyethyl)-1,3-dimethyl-;SDZ MKS 492,SDZMKS 492
CAS:114606-56-3
MF:C20H27N5O6
MW:433.46
EINECS:
Product Categories:
Mol File:114606-56-3.mol
SDZ MKS 492 Structure
SDZ MKS 492 Chemical Properties
Boiling point 648.7±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (576.75 mM; Need ultrasonic)
form Solid
pka14.25±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
SDZ MKS 492 Usage And Synthesis
UsesSDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].
in vivo

MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].
MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].
MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].
MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1].

Animal Model:Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum[1]
Dosage:3, 10 mg/kg
Administration:I.v. 5 min before antigen challenge
Result:Inhibited antigen-induced bron choconstriction in a dose-related manner.
References[1] Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13. DOI:10.1254/jjp.63.405
[2] Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10. PMID:1793072
SDZ MKS 492 Preparation Products And Raw materials
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