deramciclane

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deramciclane Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

deramciclane manufacturers
deramciclane Basic information
Product Name:deramciclane
Synonyms:Deramciclane fumarate
CAS:120444-72-6
MF:C20H31NO.C4H4O4
MW:417.543
EINECS:
Product Categories:
Mol File:120444-72-6.mol
deramciclane Structure
deramciclane Chemical Properties
Melting point 210-213°
alpha 43620 -88.0° ± 1 (c = 0.4 in DMSO)
pka9.61(at 25℃)
Safety Information
MSDS Information
deramciclane Usage And Synthesis
UsesDeramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis[1][2].
References[1] Plvimki EP, et al. eramciclane, a putative anxiolytic drug, is a serotonin 5-HT2C receptor inverse agonist but fails to induce 5-HT2C receptor down-regulation. Psychopharmacology (Berl). 1998 Mar;136(2):99-104. DOI:10.1007/s002130050544
[2] Kriinen TM, et al. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):50-8. DOI:10.1111/j.1742-7843.2007.00145.x
deramciclane Preparation Products And Raw materials
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