methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate

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methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate manufacturers

  • GPX4-IN-4
  • GPX4-IN-4 pictures
  • $2800.00
  • 2026-05-11
  • CAS:2920221-53-8
  • Purity:
  • Supply Ability: 10g
methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Basic information
Product Name:methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate
Synonyms:methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate;GPX4-IN-4;1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methylsulfonyl)phenyl]-, methyl ester, (1S,3R)-
CAS:2920221-53-8
MF:C22H21ClN2O5S
MW:460.93
EINECS:
Product Categories:
Mol File:2920221-53-8.mol
methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Structure
methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Chemical Properties
Boiling point 702.983±60.00 °C(Press: 760.00 Torr)(predicted)
density 1.414±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 20 mg/ml
pka15.986±0.60(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Usage And Synthesis
UsesGPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1].
in vivo

GPX4-IN-4 (Compound 24; 100 and 200 mg/kg; i.p.; once) engages kidney GPX4 and induces PD markers in mice[1].
GPX4-IN-4 (50 mg/kg; i.p.; daily for 20 days) has no effect on WSU-DLCL2 tumor growth in mice, although partial target engagement is observed in tumor homogenate[1].

Animal Model:SCID/Beige mice[1]
Dosage:100 and 200 mg/kg
Administration:IP, once
Result:The GPX4 band was shifted. Engaged kidney GPX4 and induced PD markers.
Animal Model:SCID/Beige mice[1]
Dosage:30 and 100 mg/kg
Administration:IP (Pharmacokinetic Analysis)
Result:PK Properties of GPX4-IN-4 (Compound 24)[1]
Doset1/2 (h)Cmax (μg/mL)AUC (μg*h/mL)
30 (IP)0.50.92 (±0.24)1.89 (±0.17)
100 (IP)1.75.31 (±0.53)16.20 (±1.70)
References[1] Randolph JT, et al. Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo. J Med Chem. 2023 Mar 23;66(6):3852-3865. DOI:10.1021/acs.jmedchem.2c01415
methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate Preparation Products And Raw materials
Tag:methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate(2920221-53-8) Related Product Information
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