GPX4 Inhibitor 17

Request For Quotation
GPX4 Inhibitor 17 Suppliers list
Company Name: Cayman Chemical Company  
Tel: 800-364-9897
Email: sales@caymanchem.com
GPX4 Inhibitor 17 Basic information
Product Name:GPX4 Inhibitor 17
Synonyms:GPX4 Inhibitor 17
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
GPX4 Inhibitor 17 Structure
GPX4 Inhibitor 17 Chemical Properties
solubility DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
Safety Information
MSDS Information
GPX4 Inhibitor 17 Usage And Synthesis
DescriptionGPX4 inhibitor 17 is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) and an inducer of ferroptosis.1 It inhibits GPX4 activity by 49.16% when used at a concentration of 1 µM. GPX4 inhibitor 17 (0.5 µM) increases the production of reactive oxygen species (ROS) and levels of malondialdehyde (MDA) in OS-RC-2 clear cell renal cell carcinoma cells. It induces ferroptosis in HT-1080 cells (IC50s = 0.007 and 1.486 µM, in the absence and presence of ferrostatin-1, respectively). GPX4 inhibitor 17 (20 mg/kg) reduces tumor volume and intratumoral GPX4 levels in an OS-RC-2 mouse xenograft model.WARNING This product is not for human or veterinary use.
References[1] LI W, YU J, WANG J, et al. How does ferrocene correlate with ferroptosis Multiple approaches to explore ferrocene-appended GPX4 inhibitors as anticancer agents†[J]. Chemical Science, 2024, 27: 10477-10490. DOI: 10.1039/d4sc02002b
GPX4 Inhibitor 17 Preparation Products And Raw materials
Tag:GPX4 Inhibitor 17 Related Product Information
GPX4-IN-6 GPX4-IN-13 methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methylsulfonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate GPX4 Inhibitor Screening Assay Kit Benzo[b]thiophene-3-acetamide, α-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)-