| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT manufacturers
|
| | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Basic information |
| Product Name: | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT | | Synonyms: | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT;ADENOSINE 5'-TRIPHOSPHATE-2', 3'-DIALDEHYDE SODIUM SALT;oATP;Adenosine 5′-triphosphate, periodate oxidized;ADENOSINE 5-TRIPHOSPHATE, PERIODATEOXIDI ZED SODIUM;adenosine 5'-triphosphate-2',3'-dialdehyde;Adenosine 5`-triphosphate sodiuM salt periodate oxidized;Oxidized ATP (oATP) - CAS 71997-40-5 - Calbiochem | | CAS: | 71997-40-5 | | MF: | C10H13N5NaO13P3 | | MW: | 527.15 | | EINECS: | | | Product Categories: | | | Mol File: | 71997-40-5.mol |  |
| | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Chemical Properties |
| storage temp. | -20°C | | form | White powder | | color | White to off-white | | biological source | bacterial (corynebacterium sp) | | Water Solubility | water: 50mg/mL | | InChIKey | IHQATUPGVKMGLT-AUCRBCQYSA-N | | SMILES | [Na].Nc1ncnc2n(cnc12)[C@H](O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=O)C=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Usage And Synthesis |
| Uses | Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
- as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
- as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
- to evaluate the physiological significance of elevated intracellular ATP levels
- increasedP2rx7expression for osteoclastogenesis inFlcn-deficient cells
| | General Description | A 2′,3′-dialdehyde derivative of ATP that is commonly used to affinity label nucleotide sites in enzymes. Acts as a specific, irreversible antagonist of P2Z/P2X7 purinergic receptors in J774 mouse macrophages. Does not affect P2γ receptors. Inhibits inflammatory pain in arthritic rat model by blocking ATP action on P2X7 receptor in nerve terminals. Also shown to irreversibly block ATP-induced Ca2+ influx in lymphocytes (100 μM). O-ATP-treated mice display better preservation and lower rate of rejection of pancreatic islet grafts with reduced Th1 transcripts. | | Biochem/physiol Actions | Reversible: no | | in vivo | Oxidized ATP (300 μg/mouse, i.p., twice a week) trisodium salt ameliorates the induced mouse experimental autoimmune uveitis (EAU) in B6 mice[2].
| Animal Model: | Induced mouse experimental autoimmune uveitis (EAU)[2] | | Dosage: | 300 μg/mouse | | Administration: | i.p. | | Result: | Showed almost undetected EAU, as shown by fundoscopic and pathologic examination.
Decreased serum IL-17 level.
Mitigated the autoreactive T cell response.
|
| | IC 50 | NLRP3 inflammasome; P2X7 Receptor |
| | ADENOSINE 5'-TRIPHOSPHATE, PERIODATE OXIDIZED SODIUM SALT Preparation Products And Raw materials |
|