A3AR modulator 1

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Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
A3AR modulator 1 Basic information
Product Name:A3AR modulator 1
Synonyms:A3AR modulator 1;3H-Imidazo[4,5-c]quinolin-4-amine, N-(4-iodophenyl)-2-(1-propylbutyl)-
CAS:2991693-62-8
MF:C23H25IN4
MW:484.38
EINECS:
Product Categories:
Mol File:2991693-62-8.mol
A3AR modulator 1 Structure
A3AR modulator 1 Chemical Properties
Boiling point 628.1±50.0 °C(predicted)
density 1.482±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka12.43±0.40(predicted)
Safety Information
MSDS Information
A3AR modulator 1 Usage And Synthesis
UsesA3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [35S]GTPγS binding Emax[1].
in vivo

In fasted Wistar rats, A3AR modulator 1 (compound 39) has considerably longer in vivo half-life and improved oral bioavailability (3.44 h, 64.0%F at 3 mg/kg; 3.84 h, 61.5%F at 10 mg/kg), indicating substantial oral bioavailability[1].

IC 50Adenosine A3 receptor
References[1] Lucas B Fallot, e al. Structure-Activity Studies of 1 H-Imidazo[4,5- c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. J Med Chem. 2022 Nov 24;65(22):15238-15262. DOI:10.1021/acs.jmedchem.2c01170
A3AR modulator 1 Preparation Products And Raw materials
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