PqsR-IN-3

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PqsR-IN-3 Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
PqsR-IN-3 Basic information
Product Name:PqsR-IN-3
Synonyms:PqsR-IN-3;4(1H)-Pyridinone, 3-hydroxy-1,6-dimethyl-2-[[[[1-(4-phenoxyphenyl)-1H-1,2,3-triazol-4-yl]methyl]amino]methyl]-
CAS:3033007-79-0
MF:C23H23N5O3
MW:417.46
EINECS:
Product Categories:
Mol File:3033007-79-0.mol
PqsR-IN-3 Structure
PqsR-IN-3 Chemical Properties
Boiling point 603.1±65.0 °C(predicted)
density 1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka9.73±0.40(predicted)
Safety Information
MSDS Information
PqsR-IN-3 Usage And Synthesis
UsesPqsR-IN-3 (compound 16e) is a selective inhibitor of the pqs system (IC50=3.7 μM) and its associated virulence factor pyocyanin (IC50=2.7 μM). PqsR-IN-3 inhibits bacterial biofilm synthesis and is significantly cytotoxic against Pseudomonas aeruginosa. PqsR-IN-3 has synergistic effects with several antibiotics, such as Ciprofloxacin (HY-B0356) and Tobramycin (HY-B0441)[1].
References[1] Miao ZY et al. 3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa. J Med Chem. 2023 Nov 18. DOI:10.1021/acs.jmedchem.3c01328
PqsR-IN-3 Preparation Products And Raw materials
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