3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione

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3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione Basic information
Product Name:3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione
Synonyms:3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione;CRBN ligand-162;2,6-Piperidinedione, 3-(4-bromo-2-chloro-6-methylphenyl)-
CAS:3036607-75-4
MF:C12H11BrClNO2
MW:316.58
EINECS:
Product Categories:
Mol File:3036607-75-4.mol
3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione Structure
3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione Chemical Properties
Boiling point 455.093±45.00 °C(Press: 760.00 Torr)(predicted)
density 1.551±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.928±0.40(predicted)
Safety Information
MSDS Information
3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione Usage And Synthesis
UsesCRBN ligand-162 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.
IC 50Cereblon
References[1] Mileti N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. DOI:10.1021/acschembio.4c00812
3-(4-Bromo-2-chloro-6-methylphenyl)piperidine-2,6-dione Preparation Products And Raw materials
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